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Exemestane CAS 107868-30-4 Anti Estrogen Steroids Aromasin Powder for Breast Cancer Treatment

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Exemestane CAS 107868-30-4 Anti Estrogen Steroids Aromasin Powder for Breast Cancer Treatment

Brand Name : ChineseHormone
Model Number : 107868-30-4
Certification : ISO9001,SGS,UKAS
Place of Origin : China
MOQ : Free samples available
Price : Negotiable
Payment Terms : T/T, Western Union, MoneyGram, BItcoins
Supply Ability : 500 kg / month
Delivery Time : 3-6 working days
Packaging Details : Discreet package or as required
Assay : 99%min
Character : White or Almost White Crystalline Powder
Grade : Pharmaceutical Grade
Packing : Discreet ways of packing for Customs pass guaranteed
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Exemestane CAS 107868-30-4 Anti Estrogen Steroids Aromasin Powder for Breast Cancer Treatment


Product name:Exemestane
Alias:Aromasin;Exemestan;6-Methylenandrosta-1,4-diene-3,17-dione
CAS:107868-30-4
MF:C20H24O2
MW:296.40
MP:155.13ºC
Assay:99%min
Appearance:White or Almost White Crystalline Powder
Grade:Pharmaceutical Grade
Storage:Shading,confined preservation


Product Name:Exemestane
Synonyms:6-methylenandrosta-1,4-diene-3,17-dione;6-METHYLENEANDROSTA-1,4-DIENE-3,17-DIONE;10,13-dimethyl-6-methylidene-7,8,9,10,11,12,13,14,15,16-decahydrocyclopenta[a]phenanthrene-;EXEMESTANE;FCE-24304;AROMASIN;Exemestan;Exemestance
CAS:107868-30-4
MF:C20H24O2
MW:296.4
Product Categories:Active Pharmaceutical Ingredients;chiral;Antineoplastic (Hormonal);Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Pfizer compounds;Steroid and Hormone;API;Anti-cancer&immunity;Inhibitors
Mol File:107868-30-4.mol
Exemestane Structure

Usage:


Developed to help fight breast cancer, Aromasin is one of the most powerful estrogen suppressing compounds.


Description:


Exemestane is an oral steroidal aromatase inhibitor that is used in ER-positive breast cancer in addition to surgery and/or radiation in post-menopausal women.


The main source of estrogen is the ovaries in premenopausal women, while in post-menopausal women most of the body's estrogen is produced via the conversion of androgens into estrogen by the aromatase enzyme in the peripheral tissues (i.e. adipose tissue like that of the breast) and a number of sites in the brain. Estrogen is produced locally via the actions of the aromatase enzyme in these peripheral tissues where it acts locally. Any circulating estrogen in post-menopausal women as well as men is the result of estrogen escaping local metabolism and entering the circulatory system.


Application:


Exemestane is an irreversible, steroidal aromatase inactivator, structurally related to the natural substrate androstenedione. It acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation, an effect also known as "suicide inhibition." By being structurally similar to enzyme targets, Exemestane permanently binds to the enzymes, preventing them from converting androgen into estrogen.


Exemestane is taken in tablet form once a day. Patients can experience side effects like nausea, anxiety, shortness of breath, abdominal pain, bone pain, and chest pain. Side effects vary widely between patients and patients should report the side effects they experience to their doctors, as some may be indicators of dangerous complications. Shortness of breath and chest pain in particular are causes for concern in patients taking exemestane.


Dosage:


For early and advanced breast cancer:

Recommended dose: 25 mg orally once daily after a meal.



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