Customization Accepted Peptides Pentadecapeptide Bpc 157 Body
BPC 157 has a strong anti-inflammatory activity in both acute and
chronic inflammation models. In fact, preliminary results in
clinical trials suggest that BPC 157 may become an important
therapeutic tool for the treatment of inflammatory bowel disease.
BPC 157 was shown to accelerate wound healing and to have a marked
angiogenic effect. In addition, it significantly facilitates the
healing of bone fracture in rats.
This peptide also exhibits an osteogenic effect significantly
improving the healing of segmental bone defect. BPC 157 accelerates
the healing of transected rat Achilles tendon and transected rat
FITC-phalloidin staining was able to demonstrate that BPC 157
induces F-actin formation in fibroblasts. Likewise, Western blot
analysis was able to detect the production and activation of
paxillin and FAK proteins.
The western blot analysis also showed that BPC 157 increases the
extent of phosphorylation of paxillin and FAK proteins without
affecting the amounts produced.
BPC 157 (Body Protection Compound-157) is a pentadecapeptide made
up of 15 amino acids. The amino acids sequence in BPC 157 is
similar to a portion of the human BPC amino acid sequence. Human
BPC is found in the gastric juice.
Experiments have shown that BPC 157 enhances the healing of wounds,
including tendons wounds such as transected Achilles tendons of
rats. The aim of this study was to investigate the probable
mechanism that BPC 157 utilizes to accelerate the healing process
in an injured tendon.
The study used two group of tendon explants of which one group was
cultured in a BPC 157-containing medium while the other group was
cultured in a medium lacking BPC 157. These cultures were
thereafter examined for tendon fibroblasts outgrowths. Such
outgrowths indicated tendon regeneration.
The results revealed that the explants' outgrowth was significantly
accelerated in the culture containing BPC 157 as compared to the
culture lacking BPC 157. Also, a MTT assay did show that BPC 157
does not directly affect cellular proliferation in a culture of
rat-derived Achilles tendon.
However, results also showed that BPC 157 significantly increased
the survival of cells under oxidative stress. Furthermore, the
Transwell filter migration assay showed that BPC 157 significantly
increased in-vitro fibroblast migration in a dose-dependent
Moreover, BPC 157 accelerated the dispersal of the fibroblasts in
culture dishes in a dose-dependent manner.
BPC 157-treated cells was significantly increased under the
H(2)O(2) stress. BPC 157 markedly increased the in vitro migration
of tendon fibroblasts in a dose-dependent manner as revealed by
transwell filter migration assay. BPC 157 also dose dependently
accelerated the spreading of tendon fibroblasts on culture dishes.
The F-actin formation as detected by FITC-phalloidin staining was
induced in BPC 157-treated fibroblasts. The protein expression and
activation of FAK and paxillin were determined by Western blot
analysis, and the phosphorylation levels of both FAK and paxillin
were dose dependently increased by BPC 157 while the total amounts
of protein was unaltered.
BPC 157 and the Gastro-Intestinal Tract
Because of the way in which BPC 157's inherent mechanics operate in
conjunction with an animal test subject's digestive tract,
scientific studies have produced several hypothetical ways in which
the peptide could provide aid regarding specific functions
pertaining to the gastro-intestinal tract.
For instance, it is thought that the peptide's wound-healing and
anti-inflammatory properties could provide aid in the treatment to
various inflammatory bowel diseases such as Chron's disease and
The anti-inflammatory properties have also allowed the peptide to
be linked to conceivable quelling the effects of periodontitis
around the teeth.
|CJC-1295 with DACv||2mg|
|CJC-1295 without DAC||2mg|
|Pentadecapeptide BPC 157||2mg|
Purely for Scientific Research
Despite the fact that there has been plenty of research on BPC 157
in relation to how it functions and the benefits that can be
derived from such functionality, it should be emphasized that the
peptide is still just intended for scientific study at this point
Because of this, any findings or observations relating to BPC 157's
overall functionality, mechanics, benefits, should exclusively be
the product of study performed in a strictly contained environment.