Estradiol benzoate (EB, E2B) (INN) (brand name Progynon-B, many
others), or oestradiol benzoate (BAN), is a semisynthetic,
steroidal estrogen and an estrogen ester – specifically, the
3-benzoate ester of estradiol – which is marketed in Europe and
elsewhere throughout the world. Estradiol benzoate acts as a
prodrug of estradiol, and hence, is considered to be natural,
|Product name||Estradiol Benzoate|
|Other name||beta-Estradiol-3-benzoate; Oestradiol Benzoate; 17beta-Estradiol
benzoate; 1,3,5(10)-Estratriene-3,17b-diol 3-benzoate;
monobenzoate; 17-beta-estradiolmonobenzoate; 17-beta-Oestradiol
Benzestrofol; Benzhormovarine; Benzoate d'oestradiol;
benzoated’oestradiol ; 17-hydroxyestra-1,3,5(10)-trien-3-yl
benzoate; (17beta)-3-hydroxyestra-1,3,5(10)-trien-17-yl benzoate;
|Appearance||white crystalline powder|
Estradiol Benzoate Descriptions:
Estradiol benzoate was introduced in 1936 and was one of the first
forms of estrogen to be marketed. Along with estradiol
dipropionate, it was one of the most widely used estradiol esters
prior to the 1950s. However, Estradiol benzoate is now little used,
having largely been superseded by longer-acting esters of estradiol
like estradiol valerate and estradiol cypionate that require less
A single dose of 2.5 mg estradiol benzoate by intramuscular
injection was found to produce plasma estradiol levels of >400
pg/mL, measured 24 hours post-injection, in a group of patients
with minimal baseline levels of estradiol (due to GnRH analogue
therapy with triptorelin).
Estradiol Benzoate Applications:
The medical uses of estradiol benzoate are the same as those of
estradiol and other estrogens. An example of an indication for the
drug is hormone replacement therapy for menopausal symptoms or
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